Harvard Medical School expert shares latest insights on genetic testing for hearing lossat Medlab Middle East
- US-based clinical diagnostics leader Dr Sami Samir-Amr addressed regional laboratory professionals today at the Clinical Genomics Interpretation Conference at the Medlab Middle East Congress
- Medlab Middle East concludes on 8 Februaryfollowing four days of networking, knowledge-sharing and business deals in the laboratory sector
Dubai, United Arab Emirates, 7February 2024:According to the World Health Organization (WHO), approximately 2.5 billion people worldwide are estimated to have some form of hearing loss by 2050, and at least 700 million will need hearing rehabilitation services by that time. Hearing loss can be caused by a number of factors,including infections, chronic diseases, environmental damage, age, and genetics.
The genetics component of hearing loss was in focus today at the opening session of the Clinical Genomics Interpretation Track at the Medlab Middle East Congress. Led by Dr Sami Samir-Amr, an Assistant Professor in the Department of Pathology at Brigham and Women’s Hospital and Harvard Medical School and Associate Director of MGB Laboratory of Molecular Medicine, the session discussed ‘Interpretation for clinical hearing loss testing: Tackling gene curation and variant classification in a genetically and phenotypically heterogeneous disease area’.
Dr Samir-Amr said at the session: “Next-generation sequencing has been used to test for genetics-related hearing loss since around 2011. Currently, there are approximately 400 genes associated with hearing loss, with 84 genes associated with non-syndromic hearing loss, and the remaining with syndromic hearing loss.”
Genetic testing for hearing loss analyses a person’s DNA to identify if any changes that are presentare known to cause hearing loss. Identifying a gene can assist health practitioners with treatment plans and provide information on how the condition may progress over time. Syndromic hearing loss means that hearing impairment is associated with other conditions, with up to 30% of hereditary hearing impairments falling under this category. Nonsyndromic hearing loss is a partial or total loss of hearing that is not associated with other symptoms. Not all of the genes that cause hearing loss are currently known.
According to Dr Samir-Amr, the reduced cost of sequencing and breakthroughs in genetics researchhave enabled laboratories to examine a wider panel of genes in recent years, which has led to an increased diagnostic rate.However, the majority of patient reports are inconclusive or negative.
Dr Samir-Amr concluded: “Currently, there are several challenges in the field of genetics testing for hearing loss, including limited evidence for genetic variantsand discrepancies in gene-disease associations and variant assessments between laboratories.”
The 23rd edition of the Medlab Middle East Congress has hosted a selection of multi-disciplinary sessions in laboratory medicine that provide up to 27.75 CME credits and up to 19 CPD credits, exceptional education, and management solutions to help lab professionals advance their skills and improve service and care in the region.
The congress concludes tomorrow (8 February) on the final day of Medlab Middle East 2024, when the Immunology, Blood Transfusion Medicine and Sustainability in the Lab conference tracks will be under the spotlight.
Dr Nawal Al Kaabi, Senior Advisor and Head of Research and Development at Hayat Biotech in Abu Dhabi, will be among a lineup of UAE-based experts discussing the Post-COVID-19 pandemic era at the Immunology conference while ‘Ensuring Management Safety’ and the ‘Use of whole blood in emergency and trauma patients’ will be addressed at the Blood Transfusion Medicine Track.
ENDS
About Medlab Middle East
As the MENA region’s most prominent medical laboratory exhibition and congress, Medlab Middle East plays a crucial role in developing the value of laboratory medicine in reshaping the future of diagnostics by providing a platform for laboratory industry leaders, including manufacturers, dealers and distributors, to share best practice, showcase innovations, collaborate and network.
Medlab Middle East stems from 15 years of growth alongside the MENA region’s largest healthcare event, Arab Health. Now in its 23rdyear, this annual medical laboratory meeting brings together exhibitors and attendees from over 180 countries.
Medlab Middle East will take place from 5 – 8 February 2024 at the Dubai World Trade Centre, Dubai, UAE. A digital event will occur from 22 January – 22 February 2024.
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